ANTI-GBM Antibodies (IF method)

The glomerular basement membrane in the kidneys helps in the filtration of waste products. The antibodies that are produced against this membrane are known as the anti-glomerular basement membrane antibodies. These antibodies induce kidney damage by attacking the capillaries in the glomerular basement membrane. When this happens, the functioning of the kidneys gets affected owing to which proteins and blood leak into the urine. Anti-GBM antibodies target the basement membrane of the lungs and damage the lungs as well. The test measures anti-GBM antibodies in the blood.

Why is the test performed?

The test may be helpful in the assessment of individuals with rapid onset of pulmonary haemorrhage or renal failure. The test may also be used as a diagnostic aid for Goodpasture syndrome.

When is the test recommended?

The test may be recommended if the patient shows the signs and symptoms that are suggestive of kidney disease (Glomerulonephritis) or kidney and lung disease (Goodpasture syndrome). Such symptoms may include:

Kidney failure

Respiratory failure

Chest pain

Chills and fever

Weight loss

Hematuria

Vomiting

Pulmonary haemorrhage (coughing up blood)

Anaemia due to bleeding.

How is the sample collected?

Venous blood is collected from a vein in the arm.

How to prepare for the test?

No special preparations are required for this test.

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