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ACTH is produced by the pituitary glands. It regulates the production of cortisol, which is produced by the adrenal glands. The hypothalamus produces corticotropin-releasing hormone (CRH) that stimulates pituitary gland to produce ACTH. Furthermore, the adrenal gland is stimulated by ACTH and produces cortisol. Therefore, proper functioning of the pituitary, hypothalamus and adrenal glands is essential for the maintenance of appropriate levels of cortisol. Some health conditions interfere with the ACTH and cortisol production in the body and to detect such conditions, ACTH levels are measured in the blood.
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