Anti CCP ( Cyclic Citrullinated Peptide Antibody )

In our body arginine normally metabolises and produces citrulline, but in conditions like rheumatoid arthritis, this conversion takes place rapidly, particularly in the joints. The citrulline alters the structure of the joint proteins and prompts an immune response, owing to which autoantibodies (cyclic citrullinated peptide antibodies) are produced against the joint proteins in the body. A cyclic citrullinated peptide antibody test detects and measures the levels of these antibodies in the blood.

Why the test performed?

The test may be performed in association with or after a rheumatoid factor test to help diagnose rheumatoid arthritis and to evaluate its prognosis. The test may also be recommended to individuals with undifferentiated arthritis in order to assess their risk of developing rheumatoid arthritis.

When is the test ordered?

A physician may recommend a CCP antibody test in conjunction with a rheumatoid factor test if an individual experiences symptoms that may be owing to previously undiagnosed arthritis. The test may also be ordered following a negative rheumatoid factor test if signs and symptoms are indicative of rheumatoid arthritis. Such symptoms may include:

Fatigue

Fever

Pain in the neck, elbow, hips and knees

Swollen and painful joints of hands and wrists

The stiffness of joints in the morning.

How is the sample collected?

A blood sample is collected from a vein in the arm.

How to prepare for the test?

No special preparation is required for the test.

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