Anti Double Stranded DNA (ds-DNA) Screening

Anti-dsDNA antibodies are produced by the immune system against the DNA when the immune system is unable to distinguish between its own antigens and foreign antigens. These autoantibodies cause organ and tissue damage. The presence of anti-dsDNA in the blood strongly indicates an autoimmune disorder. Therefore, to detect such antibodies an anti-dsDNA screening is recommended.

Why is the test ordered?

The test is helpful in the diagnosis of Lupus in patients with signs and symptoms suggestive of systemic lupus erythematosus (SLE). The test is recommended following a positive antinuclear antibody test to help diagnose lupus. It may also be ordered to monitor the progress of SLE.

When is the test recommended?

When a physician suspects lupus in an individual based on the signs and symptoms and owing to a positive ANA, then he or she may recommend the test. The signs and symptoms include:

Low-grade fever

Muscle pain

Joint pain

Fatigue

Weakness

Numbness or tingling in hands and legs

Red rash resembling butterflies on the nose and cheek

Inflammation and damage to the internal organs

How is the sample collected?

A blood sample is collected from a vein in the arm.

How to prepare for the test?

No special preparations are required for this test.

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