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Anti-hepatitis B core antibodies (anti-HBc) are mostly IgM. They appear shortly after the symptoms begin to show, in the initial acute phase of infection. These antibodies may persist for about six months after the acute phase and are detectable after the disappearance of HBsAg and before the appearance of hepatitis B surface antibody (anti-Hbs). Therefore, anti-HBc IgM is an important serological marker of a recent HBV infection.
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