Hepatitis C Virus (HCV) IgG Antibodies Confirmation

In the initial period following an infection with the HCV virus ( which is up to two months), the antibodies against the virus are usually undetectable. However, they become prevalent and detectable after the onset of the infection and its symptoms, i.e., after six months of infection. The antibodies start to decline over the years following resolution of infection. Though the test cannot differentiate between a chronic and past infection, it helps in detection of IgG antibodies.

Why is the test ordered?

The test is used to confirm the detection of IgG antibodies produced against the hepatitis C virus (HCV) in positive anti-HCV samples. It, therefore, helps in differentiating false-positive results from actual positive ones obtained from the initial antibody screening test.

When is the test ordered?

The samples that are reactive by the initial screening test (HCV antibodies test) are confirmed by the detection of HCV antibodies (IgG). Moreover, the patients in whom the initial screening test results are reactive for anti-HCV antibodies, with negative or undetectable hepatitis C virus RNA test – HCV IgG test is recommended to help differentiate between a false or non-reactive hepatitis C antibody screening test and a positive or true test.

How is the sample collected?

A blood sample is collected from a vein in the arm.

How to prepare for the test?

No special preparations are required for this test.

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