Hydroxyproline Levels Urine Test

Hydroxyproline is an amino acid present in a protein called collagen in the body. The protein collagen is found abundantly throughout the body and constitutes an important component of cartilage, bones and skin. The destruction of collagen owing to some disorders causes the release of hydroxyproline in the urine. Therefore, hydroxyproline levels in the urine can be used to diagnose such disorders.

Why is the test ordered?

A hydroxyproline urine test may be recommended in individuals who suffer from

Weakness

Bone pain

Bone deformities

Unusual bone breakage

The test also proves helpful in diagnosing a bone disorder known as Paget's disease as well as for monitoring the treatment for bone disorders. It is also useful as an adjunct in the diagnosis of Marfan syndrome.

How is the sample collected?

A urine sample (2 hour or 24 hours) is collected in a sterile container.

How to prepare for the test?

It is recommended that the patient drink a few glasses of water or other fluids prior to the test.

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